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(a) Suppression Genotype AB Phenotype Wild type (b) Synthetic lethality 1 Genotype AB Phenotype Wild type (c) Synthetic lethality 2 aB Ab Mutant Mutant aB Ab Partial Partial defect defect ab Suppressed mutant ab Severe defect INTERPRETATION A B INTERPRETATION A B AB aB Ab ab Phenotype Wild type Wild type Wild type Mutant Genotype INTERPRETATION Precursor Precursor Precursor Precursor ABaBAbab Product EXPERIMENTAL FIGURE 9-9 Mutations that result in genetic suppression or synthetic lethality reveal interacting or redundant proteins.
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